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Clinical radiation oncology : indications, techniques, and results / editor, William Small, Jr. ; associate editors, Nancy J. Tarbell, Min Yao ; section editors, Jason A. Efstathiou, Minesh P. Mehta, William Small, Jr., Christopher G. Willett, Min Yao.

Contributor(s): Material type: TextTextPublisher: Hoboken, NJ : John Wiley & Sons, Inc., 2017Edition: Third editionDescription: 1 online resourceContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9781119341154
  • 1119341159
Subject(s): Genre/Form: Additional physical formats: Print version:: Clinical radiation oncologyDDC classification:
  • 616.99/40642 23
LOC classification:
  • RC271.R3
NLM classification:
  • QZ 269
Online resources:
Contents:
Clinical Radiation Oncology; Contents; Dedication; Preface; Contributors; Section 1 Scientific Foundations; 1 Basic Concepts of Clinical Radiation Oncology; Introduction; Planning and Preparation; Radiation Therapy in the Clinic; Combining Radiation Therapy with Surgery; Preoperative Radiation Therapy; Postoperative Radiation Therapy; Combining Radiation Therapy with Chemotherapy; Combining Radiation Therapy with Biologic Agents; Combining Radiation Therapy with Hormonal Agents; Radiosensitivity and Tumor Control Probability; Fractionation and Fraction Size
Linear Energy Transfer (LET) and Relative Biologic Effectiveness (RBE)Oxygen Enhancement Ratio; Radiocurable Tumors; Technological Advances in Radiotherapy; Intensity-Modulated Radiation Therapy (IMRT); Image-Guided Radiotherapy (IGRT); Stereotactic Radiosurgery (SRS)/Stereotactic Body Radiation Therapy (SBRT); Particle Beam Radiotherapy; Brachytherapy; Intraoperative Radiotherapy; Unsealed Sources; Hyperthermia; Radiation Complications; References; 2 Radiation Biology for Radiation Oncologists; DNA Damage, DNA Repair, and Cell Survival; DNA Damage After Irradiation
Immediate Biochemical Modification of Radiation-Induced DamageDNA Damage Sensing and DNA Repair; Modes of Cell Death Following DNA Damage; Biological Factors that Influence Radiation Response; The Oxygen Effect and the Significance of Hypoxia; Radiation Sensitivity, the Cell Cycle, and Checkpoints; Physical Parameters Affecting Radiation Response; Dose Rate; Linear Energy Transfer and Relative Biological Effectiveness; Tumor and Tissue Responses to Ionizing Radiation; Dose-Response Curves and the Therapeutic Window; Tumor Cell Radiation Sensitivity
Dose-Response Curves for Tumors Irradiated In SituSlope of Dose-Response Curve and Heterogeneity in Treated Tumors; Tumor Volume and TCD50; Recurrent Tumors; Immune Reaction and Tumor Response; Normal Tissue Response; Attempts to Reduce the Impact of Hypoxic Cells on Tumor Resistance; Dose Fractionation and Tissue Response; Biological Significance of Dose Fractionation; Models of Fractionation Dependence; Combination of Radiation and Chemotherapeutic Agents: Cytotoxics, Sensitizers, and Protectors; Radiation Protectors; Rationale for the Combination of Surgery and Radiotherapy
New Approaches to Optimize Radiation TherapyInhibition of Kinase-Dependent Signaling Pathways to Enhance Radiotherapy; Modulation of Apoptosis to Increase Tumor Cell Kill or Protect Normal Tissues; Angiogenesis as a Target for Cancer Therapy; Summary; References; 3 Treatment Planning; Introduction; Imaging; Imaging for Treatment Planning; Computed Tomography; Magnetic Resonance Imaging; Emission Tomography; Image Processing; Image Registration; Deformable Image Registration (DIR); Image Segmentation; Dose Calculations; Single-Field Dosimetry
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Includes bibliographical references and index.

Description based on print version record and CIP data provided by publisher.

Clinical Radiation Oncology; Contents; Dedication; Preface; Contributors; Section 1 Scientific Foundations; 1 Basic Concepts of Clinical Radiation Oncology; Introduction; Planning and Preparation; Radiation Therapy in the Clinic; Combining Radiation Therapy with Surgery; Preoperative Radiation Therapy; Postoperative Radiation Therapy; Combining Radiation Therapy with Chemotherapy; Combining Radiation Therapy with Biologic Agents; Combining Radiation Therapy with Hormonal Agents; Radiosensitivity and Tumor Control Probability; Fractionation and Fraction Size

Linear Energy Transfer (LET) and Relative Biologic Effectiveness (RBE)Oxygen Enhancement Ratio; Radiocurable Tumors; Technological Advances in Radiotherapy; Intensity-Modulated Radiation Therapy (IMRT); Image-Guided Radiotherapy (IGRT); Stereotactic Radiosurgery (SRS)/Stereotactic Body Radiation Therapy (SBRT); Particle Beam Radiotherapy; Brachytherapy; Intraoperative Radiotherapy; Unsealed Sources; Hyperthermia; Radiation Complications; References; 2 Radiation Biology for Radiation Oncologists; DNA Damage, DNA Repair, and Cell Survival; DNA Damage After Irradiation

Immediate Biochemical Modification of Radiation-Induced DamageDNA Damage Sensing and DNA Repair; Modes of Cell Death Following DNA Damage; Biological Factors that Influence Radiation Response; The Oxygen Effect and the Significance of Hypoxia; Radiation Sensitivity, the Cell Cycle, and Checkpoints; Physical Parameters Affecting Radiation Response; Dose Rate; Linear Energy Transfer and Relative Biological Effectiveness; Tumor and Tissue Responses to Ionizing Radiation; Dose-Response Curves and the Therapeutic Window; Tumor Cell Radiation Sensitivity

Dose-Response Curves for Tumors Irradiated In SituSlope of Dose-Response Curve and Heterogeneity in Treated Tumors; Tumor Volume and TCD50; Recurrent Tumors; Immune Reaction and Tumor Response; Normal Tissue Response; Attempts to Reduce the Impact of Hypoxic Cells on Tumor Resistance; Dose Fractionation and Tissue Response; Biological Significance of Dose Fractionation; Models of Fractionation Dependence; Combination of Radiation and Chemotherapeutic Agents: Cytotoxics, Sensitizers, and Protectors; Radiation Protectors; Rationale for the Combination of Surgery and Radiotherapy

New Approaches to Optimize Radiation TherapyInhibition of Kinase-Dependent Signaling Pathways to Enhance Radiotherapy; Modulation of Apoptosis to Increase Tumor Cell Kill or Protect Normal Tissues; Angiogenesis as a Target for Cancer Therapy; Summary; References; 3 Treatment Planning; Introduction; Imaging; Imaging for Treatment Planning; Computed Tomography; Magnetic Resonance Imaging; Emission Tomography; Image Processing; Image Registration; Deformable Image Registration (DIR); Image Segmentation; Dose Calculations; Single-Field Dosimetry

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