000 06707cam a2200757Ii 4500
999 _c33772
_d33772
001 on1052566417
003 OCoLC
005 20200702121305.0
006 m d
007 cr cnu|||unuuu
008 180914s2018 sz o 001 0 eng d
020 _a9783319751108
_q(electronic bk.)
020 _a3319751107
_q(electronic bk.)
020 _z9783319751085
_q(print)
020 _z3319751085
024 7 _a10.1007/978-3-319-75110-8
_2doi
035 _a1886267
035 _a(OCoLC)1052566417
_z(OCoLC)1052877409
_z(OCoLC)1054796119
040 _aN$T
_beng
_erda
_epn
_cN$T
_dGW5XE
_dN$T
_dEBLCP
_dNLE
_dYDX
_dDKU
049 _aMAIN
050 4 _aRC931.O73
066 _c(S
072 7 _aHEA
_x039000
_2bisacsh
072 7 _aMED
_x014000
_2bisacsh
072 7 _aMED
_x022000
_2bisacsh
072 7 _aMED
_x112000
_2bisacsh
072 7 _aMED
_x045000
_2bisacsh
072 7 _aMJG
_2bicssc
072 7 _aMJG
_2thema
082 0 4 _a616.7/16
_223
245 0 0 _aMultidisciplinary approach to osteoporosis :
_bfrom assessment to treatment /
_cAndrea Lenzi, Silvia Migliaccio, editors.
264 1 _aCham, Switzerland :
_bSpringer,
_c2018.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
500 _aIncludes index.
505 0 _aIntro; Preface; Introduction to Interdisciplinary Approach to Osteoporosis: Why Is It So Important?; Contents; 1: Anatomy and Physiology of Skeletal Tissue: The Bone Cells; 1.1 Introduction; 1.2 The Functions of the Bone; 1.3 Osteoclasts; 1.4 Osteoclastogenesis; 1.5 Osteoblasts; 1.6 Transcription Factors Affecting Osteoblastogenesis; 1.7 Molecules Affecting Osteoblastogenesis; 1.8 Osteocytes; 1.9 Osteocytogenesis; 1.9.1 Development and Maintenance of the Osteocytic Network; 1.9.2 Phosphate Metabolism and Matrix Mineralization; 1.9.3 Regulation of Bone Formation and Resorption
505 8 _a3.1.1 Genetic Factors3.1.2 Environmental Factors; 3.1.2.1 Alcohol; 3.1.2.2 Cigarette Smoking; 3.1.2.3 Physical Inactivity and Immobilization; 3.1.2.4 Low Body Weight and Diet; 3.1.2.5 Limited Exposure to Ultraviolet Light; 3.1.3 Reproductive History and Puberty; 3.1.4 Personal History of Fractures and Falls; 3.1.5 Drug Therapy; 3.1.6 Comorbidities; 3.1.7 Physical Examination; 3.1.8 Algorithms; 3.2 Laboratory Testing; 3.3 Bone Imaging; 3.3.1 Conventional X-ray of the Spine; References; 4: Functional Evaluation of the Subjects with Skeletal Alterations; 4.1 Introduction
505 8 _a4.2 Functional Evaluation4.2.1 Range of Motion; 4.2.2 Muscle Assessment; 4.2.2.1 Muscle Mass Assessment; 4.2.2.2 Muscle Strength Assessment; 4.2.2.3 Muscle Power and Physical Performance Assessment; 4.2.3 Balance Assessment; 4.2.4 Disability Assessment; 4.3 Pain Assessment; 4.4 Health-Related Quality of Life; References; Part I: Endocrinologicic and Metabolic Regulation; 5: Skeletal Alterations and Parathyroid Function; 5.1 Introduction; 5.2 Effect on Bone Resorption; 5.3 Effect on Bone Formation; 5.4 Primary Hyperparathyroidism; 5.5 Hypoparathyroidism
505 8 _a5.6 Effects of Parathyroid Hormone Treatment in HypoparathyroidismReferences; 6: GH/IGF-I and Bone; 6.1 Physiology; 6.2 Clinical Consequences of GH Excess and Deficiency in Humans; 6.2.1 Acromegaly; 6.2.2 GHD; References; 7: Adrenal Function and Skeletal Regulation; 7.1 Introduction; 7.2 Adrenal Gland Hormones; 7.3 Glucocorticoids and Bone Physiology; 7.4 Androgens and Bone Physiology; 7.5 Subclinical Hypercortisolism and the Bone; 7.6 Overt Hypercortisolism and the Bone; 7.7 Glucocorticoid Sensitivity and the Bone; 7.8 Congenital Adrenal Hyperplasia and the Bone
520 _aThis book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age.
588 0 _aOnline resource; title from PDF title page (SpringerLink, viewed September 18, 2018).
588 0 _aOnline resource; title from PDF title page (EBSCO, viewed September, 18, 2018).
590 _aMaster record variable field(s) change: 072
650 0 _aOsteoporosis.
650 0 _aOsteoporosis
_xDiagnosis.
650 0 _aOsteoporosis
_xTreatment.
650 7 _aHEALTH & FITNESS / Diseases / General.
_2bisacsh
650 7 _aMEDICAL / Clinical Medicine.
_2bisacsh
650 7 _aMEDICAL / Diseases.
_2bisacsh
650 7 _aMEDICAL / Evidence-Based Medicine.
_2bisacsh
650 7 _aMEDICAL / Internal Medicine.
_2bisacsh
650 7 _aMetabolism.
_2bicssc
650 7 _aOrthopaedics & fractures.
_2bicssc
650 7 _aEndocrinology.
_2bicssc
655 4 _aElectronic books.
700 1 _aLenzi, Andrea,
_eeditor.
700 1 _aMigliaccio, Silvia,
_eeditor.
776 0 8 _cOriginal
_z3319751085
_z9783319751085
_w(OCoLC)1018041888
850 _aNMUCL
856 4 0 _3EBSCOhost
_uhttp://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1886267
880 8 _6505-00
_aReferences2: Genetics of Osteoporosis; 2.1 Introduction; 2.2 Genetic Contribution to Osteoporosis; 2.2.1 Lipoprotein Receptor-Related Protein 5 (LRP5) and Lipoprotein Receptor-Related Protein 6 (LRP6) Genes; 2.2.2 Vitamin D Receptor (VDR) Gene; 2.2.3 Estrogen Receptor Alpha (ER(Sa(B) Gene; 2.2.4 Aromatase Gene (CYP19); 2.2.5 Collagen Type I Alpha I (COLIA1) Gene; 2.2.6 Transforming Growth Factor Beta (TGF-(Sb(B1); 2.2.7 Other Genes; 2.3 Novel Approaches to the Genetics of Osteoporosis: Genome-Wide Association Studies (GWAS); References; 3: Osteoporosis Diagnosis; 3.1 Clinical Evaluation
942 _2nlm
_cEBK